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Lymphotoxin alpha LTA+496C allele is a risk factor for periodontitis in patients with coronary artery disease

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Lymphotoxin alpha LTA+496C allele is a risk factor for periodontitis in patients with coronary artery disease

Auteurs : A. Palikhe [Finlande] ; M. Lokki [Finlande] ; P. J. Pussinen [Finlande] ; S. Paju [Finlande] ; J. Ahlberg [Finlande] ; S. Asikainen [Suède] ; M. Sepp Nen [Finlande] ; V. Valtonen [Finlande] ; M. S. Nieminen [Finlande] ; J. Sinisalo [Finlande]

Source :

Tissue Antigens [ 0001-2815 ] ; 2008-06.

RBID : ISTEX:8A5239D42C6049F116F0FF44F96057FE3C788ED1

Descripteurs français

Wicri :
- geographic : Finlande.
- topic : Logiciel.

English descriptors

Abstract

Periodontitis and coronary artery disease (CAD) are inflammatory diseases and associated with each other. The major histocompatibility complex (MHC) region carries genes involved in immune response and inflammation. We investigated whether the MHC genes correlate with the presence of periodontitis or with the occurrence of periodontal pathogens in patients with CAD. Blood and saliva samples from CAD patients (n = 106) were collected at the time of hospitalization. Nine MHC genetic markers [human leukocyte antigen (HLA)‐A, HLA‐B, HLA‐DRB1, lymphotoxin alpha (LTA) +253(a/g), +496(C/T), +633(c/g), +724(C/A), C4A and C4B)] were typed. Based on panoramic tomography, patients were categorized into nonperiodontitis and periodontitis groups. Two major periodontal pathogens, Aggregatibacter (Actinobacillus) actinomycetemcomitans and Porphyromonas gingivalis, were cultivated and polymerase chain reaction‐amplified from salivary samples. Serum immunoglobulin (Ig)A and IgG antibody levels to these pathogens were measured. In the univariate analysis, LTA+496C allele (OR = 5.29; 95% CI = 2.07–13.51, P = 0.00027), and the occurrence of P. gingivalis in saliva (OR = 4.74; 95% CI = 1.64–13.70; P = 0.002) were more frequent in periodontitis when compared with nonperiodontitis. Similarly, serum IgA antibody level against the pathogen was increased in periodontitis (P = 0.048). In the multiple logistic regression analysis, when a wide range of covariates was included, the LTA+496C allele (OR = 10.87; 95% CI = 3.23–36.60; P = 0.00012) and the elevated serum IgA antibody level against P. gingivalis (OR = 1.56; 95% CI = 1.05–2.30; P = 0.026) remained as significant risk factors for periodontitis. In conclusion, the major finding of this study is that the LTA+496C allele is associated with periodontitis in patients with CAD.

Url:

https://api.istex.fr/document/8A5239D42C6049F116F0FF44F96057FE3C788ED1/fulltext/pdf

DOI: 10.1111/j.1399-0039.2008.01038.x

Affiliations:

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<term>Amino acids</term>
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<term>Antibody levels</term>
<term>Atherosclerosis</term>
<term>Authors journal compilation</term>
<term>Blackwell munksgaard tissue antigens</term>
<term>Cardiovascular diseases</term>
<term>Chronic inflammation</term>
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<term>Polymerase chain reaction</term>
<term>Porphyromonas</term>
<term>Porphyromonas gingivalis</term>
<term>Power calculations</term>
<term>Present study</term>
<term>Protective haplotypes</term>
<term>Receptor</term>
<term>Receptor molecule</term>
<term>Region genes</term>
<term>Region harbors</term>
<term>Regression analyses</term>
<term>Regression analysis</term>
<term>Rheumatoid arthritis</term>
<term>Risk factors</term>
<term>Salivary samples</term>
<term>Serum antibody levels</term>
<term>Signal peptide region</term>
<term>Single nucleotide polymorphisms</term>
<term>Software</term>
<term>Susceptibility</term>
<term>Systematic review</term>
<term>Tissue antigens</term>
<term>Tumor necrosis factor</term>
<term>Univariate analyses</term>
<term>Univariate analysis</term>
<term>Unstable angina</term>
<term>Wide range</term>
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<front><div type="abstract" xml:lang="en">Periodontitis and coronary artery disease (CAD) are inflammatory diseases and associated with each other. The major histocompatibility complex (MHC) region carries genes involved in immune response and inflammation. We investigated whether the MHC genes correlate with the presence of periodontitis or with the occurrence of periodontal pathogens in patients with CAD. Blood and saliva samples from CAD patients (n = 106) were collected at the time of hospitalization. Nine MHC genetic markers [human leukocyte antigen (HLA)‐A, HLA‐B, HLA‐DRB1, lymphotoxin alpha (LTA) +253(a/g), +496(C/T), +633(c/g), +724(C/A), C4A and C4B)] were typed. Based on panoramic tomography, patients were categorized into nonperiodontitis and periodontitis groups. Two major periodontal pathogens, Aggregatibacter (Actinobacillus) actinomycetemcomitans and Porphyromonas gingivalis, were cultivated and polymerase chain reaction‐amplified from salivary samples. Serum immunoglobulin (Ig)A and IgG antibody levels to these pathogens were measured. In the univariate analysis, LTA+496C allele (OR = 5.29; 95% CI = 2.07–13.51, P = 0.00027), and the occurrence of P. gingivalis in saliva (OR = 4.74; 95% CI = 1.64–13.70; P = 0.002) were more frequent in periodontitis when compared with nonperiodontitis. Similarly, serum IgA antibody level against the pathogen was increased in periodontitis (P = 0.048). In the multiple logistic regression analysis, when a wide range of covariates was included, the LTA+496C allele (OR = 10.87; 95% CI = 3.23–36.60; P = 0.00012) and the elevated serum IgA antibody level against P. gingivalis (OR = 1.56; 95% CI = 1.05–2.30; P = 0.026) remained as significant risk factors for periodontitis. In conclusion, the major finding of this study is that the LTA+496C allele is associated with periodontitis in patients with CAD.</div>
</front>
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Lymphotoxin alpha LTA+496C allele is a risk factor for periodontitis in patients with coronary artery disease

Lymphotoxin alpha LTA+496C allele is a risk factor for periodontitis in patients with coronary artery disease

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Abstract

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